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KMID : 0357220040160030022
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Journal of Korean Society Physical Therapy
2004 Volume.16 No. 3 p.22 ~ p.31
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Inhibition of Endothelial Cell-dependent Serotonin-induced Contraction of β-endorphin and Increment of Plasma β-endorphin of Silver Spike Point Low Frequency Electrical Stimulation
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Abstract
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The purpose of this study was to demonstrate the effects of silver spike point (SSP) low frequency electrical stimulation on plasma β-endorphin activities measured by radio- immunoassay from normal volunteer and the effects of β-endorphin on 5-hydroxytryptamine (5-HT, serotonin)-induced contraction investigated by isometric tension methode in rats. The current of 3 Hz continue type, but not 100 Hz continue type, of SSP low frequency electrical stimulation significantly increased in plasma β-endorphin from normal volunteer. The endothelial cell-dependent 5-HT-induced contractions were inhibited by β-endorphin 1{mu}M. These results suggest that the β-endorphin regulates nociceptive-like substance, such as 5-HT, in part and that the SSP low frequency electrical stimulation, specifically current of low frequency of 3 Hz continue type, significantly increases plasma β-endorphin from normal volunteer.
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